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Microneedles are tiny needles, often ranging from 25 to 1000 micrometers in height that can be used to deliver drugs or other substances into the skin or other tissues. They are often arranged in arrays, which can be made of various materials such as metal, silicon, or biodegradable polymers.

When applied to the skin, microneedles create microscopic punctures that allow drugs or other substances to be delivered directly into the underlying tissues. This can improve the efficacy and safety of treatments by bypassing the skin’s natural barriers and reducing the need for injections. Microneedles can be used to deliver vaccines painlessly and without the need for a traditional needle and syringe. They also can be used to deliver drugs for a variety of conditions, including diabetes, cancer, and autoimmune diseases. So, they can be considered efficient drug delivery platforms for a wide range of diseases.

In Eipha, we use microneedles as a drug carrier. The substances that are loaded onto the microneedle are vitamins, amino acids, lipids, carbohydrates, and active ingredients against different conditions.

The microneedles are prepared through several steps using a micro-mold and a hyaluronic acid hydrogel. The molds are made of silicon and consist of, for instance, a 50×50 array with needle heights of 500 μm in a 15×15 mm2 area.

Currently, a microneedle prototype with proper physicochemical properties is produced at lab-scale and this sample has to prove its effectiveness in large-scale production. We plan to start the production phase on a larger scale in a clean room under GMP while doing the necessary tests, and we aim to reach mass production as soon as possible.

The following image is a schematic representation of our prototype produced in the laboratory and we are planning to develop our products for three different indications as follows:

UAB Eipha biosciences' Product List

Current Products

Hyaluronic acid dissolvable Microneedle for Vitiligo and Psoriasis treatment support

The cause of vitiligo is unclear, though it is thought to be an autoimmune condition, where the immune system attacks the cells that form pigment. Psoriasis is an immune-mediated inflammatory disease that has been recognized by the World Health Organization as a serious, disfiguring, disabling, no-communicable disease that represents a significant public health challenge due to its psychological, social, and economic burden. Our microneedles are more effective than the conventional treatments as the APIs can directly affect the desired site of the body

Hyaluronic acid dissolvable Microneedle as hair growth booster in Alopecia

Alopecia, a common skin disease, causes hair loss on the scalp, face, and sometimes other body areas, like under the arms or on the legs. Hair loss, also known as alopecia, can occur for a variety of reasons. Some common causes include genetic factors, hormonal changes, medical conditions, medications, stress and nutritional deficiencies. Our microneedle can locally deliver the nutrients and improve the treatment of alopecia

Hyaluronic acid dissolvable Microneedle for upper-face wrinkle reduction

One of the leading causes of wrinkles on the skin is the natural aging process, which results in a decline in collagen and elastin production. Collagen and elastin are proteins that provide structure and elasticity to the skin, but as we age, our bodies produce less of these proteins, causing our skin to become thinner, drier, and less elastic. This leads to the formation of wrinkles and fine lines. Our microneedle can provide sufficient proteins in the place and delaying the aging process

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